Hi rayna,

Welcome to GRACE. Since tumor markers really don't reliably predict what is going on with an existing lung cancer, it's not possible to make a generalization about whether a rising tumor marker at the beginning of immunotherapy indicates either progression or the pseudo-progression to which you refer. As such, if you're dealing with the type of situation you describe, I would not make any assumptions about the efficacy of the immunotherapy.

JimC
Forum moderator